D. E. Shaw & Co, L.P. – Indentures – BamSEC

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from SC 13D/A ~5 pages Endo Pharmaceuticals and the D.E. Shaw Group Agree to Settlement

from SC 13D 1 page February 13, 2008 Mr. James B. Hurlock Chairman of the Board Orient-Express Hotels Ltd. 22 Victoria Street Hamilton Hm 1179, Bermuda, Bmu By: /S/Julius Gaudio Julius Gaudio Managing Director CC: Mr. Paul M. White President, Chief Executive Officer

from SC 13D 5 pages July 27, 2007 Mr. Peter Lankau Chief Executive Officer Endo Pharmaceuticals Holdings, Inc. 100 Endo Boulevard Chadds Ford, Pa 19317 Dear Mr. Lankau: As You Are Aware D. E. Shaw Composite Portfolios L.L.C. and Certain of Its Affiliates (Collectively “We” or the “D. E. Shaw Group”) Beneficially Own Approximately 5.6% of the Outstanding Shares of Endo Pharmaceuticals Holdings Inc. (“Endp” or the “Company”)