| Date | Owner | Type | Security | Price | Units | Value | |
|---|---|---|---|---|---|---|---|
| Essex Woodlands Health Ventures Fund VII LP | U | Common Stock | |||||
| Eastman Ronald W | D | Director Stock Option (Right to Buy) | |||||
| Eastman Ronald W | U | Common Stock | |||||
| Thomas Robert | D | Director Stock Option (Right to Buy) | |||||
| Sweemer Timothy D Chief Accounting Officer | D | Common Stock |